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While progress in the last 5 years has been significant, much remains to be uncovered to bring these advances to the clinic and thereby alleviate the dramatic consequences of type 2 diabetes complications for the hundreds of millions of people who live with this disease

Whether the sustained reduction in HBsAg levels achieved with siRNAs and ASOs will result in HBsAg clearance over time remains to be determined

however, it is important to also emphasize the evidence that hypertensive stimuli, such as high salt and AT-II, promote the production of ROS not only in the vasculature but also in the kidney and the central nervous system

2023;12(10):2911-2922.[DOI] 213

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