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Statements Data availability statement All metabolomics data for Steroid hormone biosynthesis metabolism is associated with fatigue related to androgen deprivation therapy for prostate cancer was deposited in the Open Science Framework database ( under the DOI number 10.17605/OSF.IO/SVEQK

These results demonstrate the effects of apoE on the pathogenesis of tauopathies, as well as tau-mediated neurotoxicity, and provide supporting evidence that the role of apoE is isoform-dependent

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Selecting the most relevant descriptors among them poses a significant challenge, as they encapsulate molecular characteristics responsible for the observed biological activity or chemical properties (290)