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Resveratrol: French paradox revisited
-KG can promote ROS generation through the tricarboxylic acid cycle to enhance the mTOR-mediated metabolic pathway, and it can also alter chromatin accessibility by affecting histone methylation, thereby promoting cell differentiation (196)
Two structural changes drive the difference
For panel c , the single plot corresponds to sibling-sibling pairs
In reproductive tissues, this results in faulty cell signaling, damaged gamete DNA, and disrupted tissue function, all of which are important for fertility
Herrera E, et al
