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doi: 10.1002/bab.2303 138 MehdizadehAKarimiEOskoueianE

Interestingly, a retrospective cohort study highlighted that cigarette smoking appears to be negatively associated with DIH, which is surprising as induction of CYP2E1 in smokers is expected to increase exposure to toxic metabolites (Zaverucha-do-Valle et al., 2014)

Ethics declarations Competing interests This review was written in the framework of the PhD research projects of C.D., I.E., and S.A

Keywords: calcium signaling, EAAT, excitotoxicity, glutamate, neurotoxicity, NMDA, Pb, synaptic plasticity 1

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Standardization of Phytocannabinoid Products Standardization efforts should align with regulatory requirements set forth by governing bodies such as the FDA or the European Medicines Agency (EMA)