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Uricase-based gout treatments are generally limited due in part to the accumulation of H2O2 in an arthrosis microenvironment

It is also used to help optimize fat metabolism for maintaining healthy weight levels

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However, mutation and overexpression studies show that glutathione competes with protein thiols for the oxidizing machinery

While offering advantages over conventional treatments, the optimization of CDT efficacy presents challenges stemming from suboptimal catalytic efficiency and the counteractive ROS scavenging effect of intracellular glutathione (GSH)