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Covalent aggregates form when monomeric proteins become chemically crosslinked, e.g., though disulfide bonds

Furthermore, as hormones can also affect hair growth [60], serum T and E2 levels in the mice were measured using ELISA kits, and the results indicated no significant variations in the T/E2 ratios in mice treated with CaT-ME or CaT, implying that these systems did not alter hormonal homeostasis in mice (Figure S10 and 11)

doi: 10.3389/fimmu.2022.937555 53

Pentecost, M., Otto, G., Theriot, J

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Collectively, these studies demonstrate that aberrant LD accumulation in microglia represents a hallmark of dysfunctional, pro-inflammatory microglial states in the aging brain and is a consistent feature across neuroimmune-associated neurodegenerative pathologies