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This flies in the face of other research that has suggested a possible mechanism linking red meat consumption to heart disease.[18,19] In May 2022, research published in the Journal of the American Medical Association found that TMAO levels in older adults were positively associated with a higher risk of death whether deaths were related to cardiovascular disease or another disease.[18] In fact, individuals in the study with the highest levels of plasma TMAO had a 20-30% higher risk of death compared with those having the lowest levels