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Clin Epidemiol

When comparing psoriatic arthritis (PsA) to cutaneous psoriasis (PsC), the former displayed a more pronounced upregulation of mucic acid and saturated fatty acids and a downregulation of tyramine and vitamin-associated pathways (124)

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Dose-dependent biphasic effects are often observed, where low concentrations may provide essential trace elements that promote cellular proliferation, while exceeding threshold levels can induce oxidative damage to membranes and metabolic dysfunction [164]

Central role of mitochondrial dysfunction Mitochondria serve not only as cellular powerhouses but also as molecular hubs regulating multiple cell death pathways