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( FIGURE 1 2.1 NO synthase isoforms and their roles in CRC Each isoform plays a unique role in the pathophysiology of CRC, as mentioned in Table 1

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doi: 10.1016/j.cell.2022.06.003 70 BouchaouiHMahoney-SanchezLGaronGBerdeauxOAllemanLYDevosDet al
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Mutual regulation of TLR/NLR and CEACAM1 in the intestinal microvasculature: implications for IBD pathogenesis and therapy

In the presence of iron ions, superoxide acquires a second electron, leading to hydrogen peroxide formation, which generated the extremely reactive hydroxyl radical
