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doi: 10.1111/pcn.12175 54 ChenKTWuCHTsaiMHWuYCJouMJHuangCCet al

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These two residues are believed to influence the physicochemical properties and the redox potential of the active center and either enhance or impair the hydroxylation of monophenols by changing the ability of water molecules to deprotonate monophenolic substrates 21

BPC-157 helps protect the site from oxidative stress while TB-500 enhances flexibility and mobility by supporting the structural integrity of connective tissues

The intranasal delivery of Apelin-13 provides a noninvasive method for directly administering the peptide therapy to the brain and bypassing the BBB [155]