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Combination therapy leads to supraphysiologic levels of T3, which may lead to symptoms of thyrotoxicosis T3 has a shorter half-life than T4, which can lead to fluctuations in T3 levels, with a peak occurring shortly after dosing There is substantially more data from trials on the use of levothyroxine compared to combination therapy In my experience, patients who are on animal-derived combination products have already tried synthetic levothyroxine and feel that the combination products control their symptoms better

A., Warner, K

"Meta-analysis of ALCAR vs placebo in MCI and mild Alzheimer's." Int Clin Psychopharmacol 2003;18:61-71

101 It seems reasonable to speculate that diabetes-associated hyperglycemia and high-glucose diet might promote tumor development by upregulating the protein acetylation described above

U., Caruso, U., Cravotto, E., D'Iddio, S., Corsi, M., Pola, P., Savi, L., and Grilli, M