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Ethanol, acetone, benzyl benzoate, and DMSO showed no evident toxicity on naive cochlear explants

Much simpler than topical applications

The mature domains of GDF11 and GDF8 are similar but not equivalent Because GDF8 and GDF11 mature domains differ only by 11 amino acids, it has long been assumed that the GDF11 and GDF8 ligands would signal similarly

It stabilizes cellular membranes, reduces oxidative stress, and prevents apoptosis (cell death) in damaged tissues

Additional research is needed to elucidate the mechanisms that control holo-TC homeostasis in the normal population and in pathologies that alter vitamin B 12 transport and utilization

Patients describe a profound, unrelenting exhaustion that does not improve with rest and is dramatically worsened by physical or cognitive exertion, a pattern called post-exertional malaise (PEM)