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A clear comparison table is also included for easy reference

Nierman, Frank C

Science 350(6262):830834 Pelaseyed T, Bergstrm JH, Gustafsson JK, Ermund A, Birchenough GMH, Schtte A et al (2014) The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

The advantage is minimal injection volume

Patient-derived xenografts propagated in humanized mice offer a potential path to overcome these limitations by combining patient-derived tumour tissue with a reconstituted human immune system

For example, successful efforts to develop ligands targeting the orthosteric (glutamate) binding site of mGlu receptors have produced amino acid analogs, which often do not possess pharmacokinetic properties suitable for human dosing (Conn et al., 2014