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Limitations of the Efficacy of C-Met Inhibitors A large number of clinical trials have proved that the safety of HGF or c-Met inhibitors is reliable

On the other hand, some drawbacks that brain organoid protocols collectively share are limited oxygen and nutrient diffusion with consequent necrosis, cellular immaturity, and the absence of certain cell types found in the brain, such as microglia and vascular cells ( Another important limitation of current protocols includes the lack of vasculature in the generated brain organoids that limits the supply of nutrients and oxygen to the organoid core

TosicMOttJBarralSBovetPDeppenPGheorghitaFet alSchizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene

Footnotes 1.^ (accessed May 16, 2022)

Facilitates the transfer of a methyl group from 5-methyltetrahydrofolate (5-methyl-THF) to homocysteine, forming methionine

[PubMed 2816958] 1490