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PloS One 4(8):e6623

Here, we reveal that the aldehyde derivative of UNC10088 promotes cooperative binding of FBXO22 to NSD2, a histone methyltransferase and oncogenic protein, leading to a cryo-EM structure of the SKP1-CUL1-F-box (SCF)-FBXO22 complex with NSD2

solvent B was 0.01% HCOOH in MeCN

Further investigation is needed to reveal whether skin microbes contribute to this process via altered community composition and dysregulated interactions with surrounding epidermal cells (Fig

Burk RF
