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The zebrafish modelcharacterized by high-throughput screening capacity, optical transparency, genetic tractability, and cost efficiencyis rapidly transitioning from a basic research tool to a pivotal platform bridging mechanistic investigation and clinical translation (Figure 5A) (Patton et al., 2021
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This minimum intensity remains the same beyond a certain time limit called useful time
Confirmation of altered postsynaptic structure with A treatment, which correlates with synaptic efficacy, was obtained via volumetric assessment of the PSDs in spines using 3D analysis
Trx1 is showing good efficacy with no major side effects (unpublished data)
These can then feed into a variety of biosynthetic pathways for elongations and other modifications
