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Replicative endothelial cell senescence may lead to endothelial dysfunction by increasing the BH2/BH4 ratio induced by oxidative stress, reducing BH4 availability, and decreasing the expression of eNOS

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Cerebral ischemia and neuronal damage resulting from Alzheimers disease (AD) and multi-infarct dementia (MID) may lead to the progression of symptoms of cognitive deficits [36]