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Increases cellular NAD and SAM availability and lowers intracellular 1-MNA, consistent with enhanced NAD salvage and a favorable methyl economy [13]

Theoretical concerns Copper accumulation: Each 2mg injection contributes about 0.03mg copper versus 0.9-2.2mg from daily diet

Jun 2017;40(3):94-97

Anyone taking methyl-donor-sensitive medications (some psychiatric drugs, methotrexate, methylated B-vitamin protocols at high doses): NNMT shares the methyl donor SAM, so theoretical interactions exist

An end-loop ileostomy made by bringing a loop proximal to the stapled-off distal segment is brought out, often chosen when there are difficulties in getting the bowel to reach 2 cm above the surface due to the shorter divided mesentery associated with a true end ileostomy, while in an end-loop the intact mesentery supplying the loop allows for additional length

Consider supplementation if dietary intake seems inadequate