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The standard protocol based on clinical research and community experience: Fasted administration is important for AOD-9604 because food can interfere with its lipolytic activity

B12 is essential for healthy nerve cells and the production of myelin, the protective covering for nerves

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This difference may be explained by the results of in vitro binding studies, which showed that daratumumab can directly bind CD38 on RBCs, whereas isatuximab requires a cofactor (e.g., a mouse anti-CD38 antibody or a CD38 inhibitor), suggesting masking of the isatuximab epitope on RBCs in some patients [49, 50]