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Glycosidase-cleavable linkers are designed to undergo enzyme hydrolysis of glycosidic bonds by specific glycosidase, which are predominantly localized in lysosomal and, in certain tumors, enriched or released into the tumor microenvironment

Crow's feet from smiling, forehead lines from raising eyebrows, and "eleven" lines between the brows from frowning all fall into this category

Diabetes Care 2011;34: 14811486

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Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto's thyroiditis: A prospective randomized-controlled trial