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USA 89 , 21152119 (1992)

Challenges include an acidic microclimate inducing protein aggregation (neutralization with MgCO3), incomplete release of hydrophilics, and scale-up variability

Oxidative stress occurs when there's an imbalance between free radicals (unstable molecules that damage cells) and antioxidants (the molecules that neutralize them)

doi: 10.1002/hep.1840150631

Increased sebum production results in localized imbalance of fatty acid abundance in skin, with locally decreased levels of LA, which is replaced by sebaleic acid, in follicular epithelium

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