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Aging, smoking, infection, genetic predisposition, abnormal biomechanical loading (such as long-term bending or heavy lifting), and reduced nutrient supply through the cartilage endplate are all inducing factors (Wu et al., 2021)

In families of patients with PA (pernicious anaemia), ulcerative colitis, rheumatoid arthritis, polymyalgia, psoriasis, sarcoidosis, lupus were in one study more common than in those of people without PA

The dosage is preferable in the range from 10 -5 to 10 -2 mg/kg of body weight, applied systemically or topically in higher concentration between 0.1% to 0.5%

A separate 2025 pilot evaluated intravenous infusion at 10 mg and 20 mg in two adults with no adverse effects on organ biomarkersbut two subjects do not constitute a trial

Vitamin D as an early predictor of multiple sclerosis activity and progression
