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81 in 2016, capitalizes on the elevated levels of H 2 O 2 and the mildly acidic conditions prevalent within the tumor microenvironment (TME) 82
79 As mentioned above, epigenetic alterations take place when methyl groups are added to or removed from a cytosine base (C) of DNA or when modifications are made to proteins called histones that bind to the DNA in chromosomes

Journal of proteome research 16, 29933001
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Finally, some of the main human disorders caused by defects in proteins underpinning the FeS biogenesis machinery will be discussed
