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We displayed the E2E1 immunogens on two-component nanoparticles and these nanoparticles induce significantly more potent neutralizing antibody responses than E2
Key mechanisms include activation of the fibroblast growth factor receptor (FGFR) axis to drive tissue repair, modulation of the nitric oxide system governing vascular tone and inflammation, and interaction with AKT/mTOR and MAPK/ERK pathways involved in cell survival and proliferation
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