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Also of note, nAbs to HIV were shown to be effective in monkeys in controlling infection in some circumstances 160,161 , as well as subsequently in some humans, suggesting a potential role for nAbs in therapy and even cure of HIV 162,163,164

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The presence of Ala88 in VP1 of wt PV2 compared with Tyr75 at this position in the CVB3-CP17 structure avoids a steric clash that would otherwise disrupt the orientation of the compound in the wt PV2-CP17 complex (Fig