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Methylation represents a critical epigenetic marker on DNA and histone substrates [73] (Figure 1)

Besides, there are many drugs targeting AH inflammation in clinical trials, including IL-1blocking Ab (Canakinumab), FXR agonist obeticholic acid (OCA), pan-caspase inhibitor (Emricasan), and endogenous epigenetic regulator DUR-928 (Peeraphatdit et al., 2018

Oral glutathione bioavailability typically ranges from 525% in healthy individuals, primarily due to rapid degradation by intestinal peptidases before systemic absorption

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V-set and immunoglobulin domain-containing 4 (VSIG4), a type I transmembrane receptor found in tissue-resident macrophages, has been shown to have anti-inflammatory effects on immune-related illnesses (84)