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Researchers have used collagen peptides to examine extracellular matrix effects on reproductive tissues

It decreased GPx activity and GSH content, downregulated GCLC/GCLM expression and then amplified the oxidative signal and weakened the cellular protection

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In this process, THF converts to methyl-THF, which is subsequently used for purine synthesis and the re-methylation of homocysteine (via the methionine-recycling pathway) [13]