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Long-term LC supplementation has been shown to elevate fasting plasma TMAO levels, raising concerns about its implications for cardiovascular health, despite its potential benefits in improving muscle mass and physical performance

The efficacy of the supplement was particularly evident during the post-treatment phase, as illustrated in Graph 1

Quantitative analysis was carried out using the Image J program (National Institutes of Health, NIH, Bethesda, MD, USA) including data from at least three independent experiments

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doi: 10.1001/jama.2020.12839 21