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These reductions were lower than those observed in patients with type 2 DM, as demonstrated in the SURPASS1 trial, where the treatment difference in HbA1C compared with placebo ranged from 1.91 to 2.11 across various doses of tirzepatide [27]
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Unfortunately, blocking PrP endocytosis in a specific manner is challenging because endocytic internalization of PrP occurs via different pathways and relies on different interactors 40,41,42,43
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