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Future developments in the field There is potential that metformin could be beneficial in the task of counteracting aging and clinical studies imply that metformin may have positive effects on cognition in T2DM patients

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Injury severity score (ISS) and Glasgow coma score (GCS) result from the injury event and occur after alcohol ingestion, making them intermediate outcomes rather than baseline characteristics

The relevant considerations shift to the biological and practical: mechanism, safety profile, protocol design, and sourcing quality

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