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Some researchers are exploring combining tesamorelin with retatrutide to add growth hormone releasing hormone (GHRH) effects on top of the triple agonism

A JAMA Psychiatry study published in February 2025 showed semaglutide significantly reduced drinking episodes in patients with alcohol use disorder through GLP-1 receptors in the mesolimbic dopamine system that modulate reward processing

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A new baseline was reached prior to the second GLP-1 infusion

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