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Conditional deletion of the p85 gene in skeletal muscle and heart showed normal growth [68], but when these mice were crossed with p85 null mice, the resulting double-mutant animals showed reduced heart but not reduced skeletal muscle size [68]

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While BSO-treated tumors only showed a trend toward an enrichment of ASCL1+ cells, Auranofin-treated tumors presented with a significantly reduced ASCL1 score (Fig

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