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Animal studies demonstrate that chronic tesofensine treatment produces sustained weight loss even as tolerance to the hypophagic effect gradually develops, indicating additional factors beyond appetite regulation contribute to maintaining maximal weight loss

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Never increase more than 100mcg at a time, and allow at least one week at each dose before further adjustment

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Sarcopenia is a progressive skeletal muscle disorder characterized by a decline in muscle mass, strength, and gait speed 124,249,250

The symptoms are more common at the start of treatment
