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However, both compounds elevate sympathetic tone to some degree (cagrilintide indirectly via vagal signalling, tesofensine directly via norepinephrine reuptake inhibition), so cardiovascular monitoring would be essential

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Introduction Synaptic vesicle (SV) recycling, one of the most complex and well-regulated processes at neuronal presynapses, is responsible for the efficient and rapid release of neurotransmitters by exocytosis and the subsequent reuse of SVs 1