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In a study, it was determined that MTHFR hypermethylation gene promoter occurs often in sperm obtained from infertile individuals, and it is relatively more common in males with a history of spontaneous abortion than in men without a history of spontaneous abortion, and it oftentimes impact the entire population of sperm

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52 Pharmacotherapy The first specific treatment for obesity due to a single gene defect for leptin deficiency in the form of recombinant leptin therapy, which reduces appetite and increases satiety, resulting in weight loss, was first approved by the FDA in February 2014