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Staments P and Chilton JS

While vitamin C is quite possibly an effective substance, the amounts required for these therapeutic effects are obviously beyond dietary intakes

On the other hand, excessive VitE toxicity has been linked to headaches, weariness, dizziness, intestinal irritation, prolonged prothrombin time, and difficulty with the absorption of vitamins A and K

[DOI] [PMC free article] [PubMed] [Google Scholar] 256.Wu Q, Deng J, Fan D, Duan Z, Zhu C, Fu R, et al

This dose-tolerability relationship provides useful guidance for clinical protocol development

RIBBON-2: a Randomized, Double-Blind, Placebo-Controlled, Phase III Trial Evaluating the Efficacy and Safety of Bevacizumab in Combination with Chemotherapy for Second-Line Treatment of Human Epidermal Growth Factor Receptor 2-negative Metastatic Breast Cancer