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Ligand binding locks the inactive conformation and ensures very low spontaneous thermal activation of the receptor, in the dark state what is referred to as dark noise 4

doi: 10.1038/s41392-024-02095-6 [DOI] [PMC free article] [PubMed] [Google Scholar] 56.Wan X, Song L, Pan W, Zhong H, Li N, Tang B

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Optimized human intestinal organoid model reveals interleukin-22-dependency of Paneth cell formation