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Therefore, the relatively low abundance of lipoylation in untreated cells suggests that lipoylation is rate-limiting for the OGDHc, and our findings are consistent with the accumulation of Lp glu following ABHD11 inhibition, which reduces OGDHc activity (Fig

Repeated bloodbrain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: A phase I/II clinical trial

In contrast, astrocytes exhibit lower expression of pyruvate dehydrogenase (Laughton et al., 2007), which limits oxidative phosphorylation (Itoh et al., 2003) and reduces pyruvate utilization efficiency in the TCA cycle (Rahman et al., 2020)

Acknowledgements This work was supported by National Natural Science Foundation of China (82170873, 82371424), and Tsinghua University Spring Breeze Fund (20211080005)

We confirmed that the mRNA expression of tyrosine hydroxylase ( TH ), a dopaminergic neuronal marker, was not significantly altered by the knockdown of ALK5 , SMAD2 , SMAD3 , or DYNLRB1 in untransduced cells, aSyn-overexpressing cells, and GFP-expressing cells (Supplementary Fig

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