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It is important to distinguish the normal physiological decrease in GH secretion associated with aging from true pathological AGHD

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Ma, C., Chen, C., Jia, L., He, X

While applied itaconate did not affect the cellular pathways investigated, OI stimulated glycolytic lactate production and Mrp1-mediated GSH export

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Notably, lactate-derived lactylation correlates with higher S-AKI incidence and poor prognosis in clinical sepsis patients
