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The findings come from the latest GLP-1 study 2025, where researchers reported meaningful reductions in body weight, improved blood sugar control, and benefits for adults living with type 2 diabetes and obesity

Additional research has also explored other retinal and optic nerve findings, including diabetic retinopathy progression and paracentral acute middle maculopathy, as investigators work to better understand the potential long-term effects of GLP-1 medications on ocular health

The use of GLP-1 RA was associated with a less steep eGFR slope compared with basal insulin in the AT analysis (mean annual between-group difference of 0.42 mL/min/1.73 m 2 /year [95%CI 0.110.73]

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Hepatic function plays a minimal role in GLP-1 elimination, as these medications are primarily degraded by proteolytic enzymes throughout the body rather than hepatic metabolism

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