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3 The distinct immunomodulatory characteristics of the gut microbiota in pneumonia Increasing evidence supports the concept of a common mucosal immune response, highlighting the potential influence of gut microbial community and its metabolites on mucosal immunity, potentially extending to distant sites such as lung immune responses ( Interestingly, the gut microbiota plays a crucial role in regulating the spatiotemporal dynamic balance of the mucosal immune system and exhibits distinct immune regulatory characteristics in bacterial, viral, and fungal pneumonia

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Goffredo, P, Quezada-Daz, F, Garca-Aguilar, J, Smith, JJ

Notably, p53 activates PCDHB14 and inhibits SLC7A11 expression by enhancing p65 protein ubiquitination-mediated degradation, thereby abrogating p65 bind to the SLC7A11 promoter (Zhao et al., 2022)