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This behavior of the GS flux is caused by the competition between the higher inhibition of GS and GCL by GSH and the higher stimulation of GCL by estradiol [Figure 2]

For a summary of the worker findings, see Table 1

Updated results from MONALEESA-2, a phase III trial of first-line ribociclib plus letrozole versus placebo plus letrozole in hormone receptor-positive, HER2-negative advanced breast cancer

The prolonged use of DA has been associated with tardive dyskinesia, an irreversible movement disorder [54]