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Do not force large meals if your appetite is low

While bupropion works in the brain on dopamine and norepinephrine, tirzepatide works primarily in the gut, the pancreas, and appetite centers in the hypothalamus

So, I do think [the drugs] are worthwhile, even if the weight comes back. Read more:

"When we stop these medications, especially, the hunger comes back very strongly, so there is a large association between stopping the medication and having that weight regain," says Dr

Perry T, Lahiri DK, Sambamurti K, et al

Clinical trials have long been the foundation of evidence generation, but they are often slow, costly, and limited in how well they reflect real-world patient populations