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Glutathione plays a key supporting role in this process by helping to neutralise and prepare certain oestrogen metabolites for safe removal

10.1016/j.bcp.2010.04.004 Biochem

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Notably, the lesional skin of patients with rosacea was shown to express more KLK-5 than the skin of healthy controls [12]

Yes, especially for correcting a deficiency

Hence, we are interested to identify multiple biomarkers to evaluate the skin irritancy potential of various metallic compounds, specifically, copper compounds