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Bode-Boger SM, Boger RH, Galland A, Tsikas D, Frolich J: L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship

This enzyme decline led researchers to link low ALCAR with low acetylcholine, and Alzheimers onset

In this Review, we describe the evidence for abnormalities in energy metabolism and mitochondrial function in migraine, with a focus on clinical data (including neuroimaging, biochemical, genetic and therapeutic studies), and consider the relationship of these abnormalities with the abnormal sensory processing and cerebral hyper-responsivity observed in migraine