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Dash M, et al

The loss of PIK3R4 inhibits autophagy and lipid catabolism through the accumulation of PPARA repressors, such as histone deacetylase 3 (HDAC3) and nuclear receptor corepressor 1 (NCOR1) (Iershov et al., 2019)

While AOD 9604 is not a muscle-building peptide, its selective fat-targeting mechanism means more of the weight lost comes from fat rather than lean tissue

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10.1038/s41586-020-2781-z Nature 58 KuhnS

597 RNA sequencing analysis showed that FTH1 was abnormally expressed in the PD rat model