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Shaking denatures the peptide and destroys its effectiveness

Lancet Diabetes Endocrinol 10: 623633

Pathare contributed equally
Maecki MT, Batterham RL, Sattar N, Levine JA, Rodrguez , Bergman BK, Wang H, Ghimpeteanu G, Lee CJ

Nature 536 , 104107 (2016) Scheerer, P

For patients with type 2 diabetes, other medication classes with fewer gastrointestinal effects might be preferable, such as SGLT-2 inhibitors or DPP-4 inhibitors