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Excess heme upregulates heme oxygenase 1 and promotes cardiac ferroptosis in mice with sickle cell disease

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This upregulation of CYP2E1 explains, in part, the metabolic tolerance to alcohol and the cross-tolerance to other drugs that are also substrates of CYP2E1, such as pentobarbital and diazepam, in people with AUD (90)

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Insufficient B12 levels can lead to neural tube defects in the developing fetus
