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Samuels M: Manual of Neurologic Therapeutics

We need to observe safety, accessibility, and overall impact on daily life

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Of interest is the finding that the enzyme is active with cystathionine, djenkolic acid, lanthionine, and cystine, suggesting that the enzyme is similar to PLP-dependent cystathionine - and -lyases

They take advantage of the high levels of protease activity inside lysosomes and typically include a peptide sequence that is recognized and cleaved by these proteases, e.g., as occurs with a dipeptide Val-Cit linkage that is rapidly hydrolyzed by cathepsins
