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Together, our observations that a small molecule NNMT inhibitor can increase NAD + and SAM concentrations in differentiated adipocytes and reduce adiposity in DIO mice, suggest that treatment with an NNMT inhibitor effectively reverses obesity via modulation of the NAD + salvage and SAM-mediated (e.g., polyamine flux) pathways to regulate energy expenditure in the adipose tissue

Parsons RB, Facey PD (2021) Nicotinamide N -methyltransferase: an emerging protagonist in cancer macro (r) evolution

Tables 1 and 2 summarize passive membrane diffusion and active transport membrane permeability, respectively, for select small molecule NNMT inhibitors for which structure activity relationships had been previously developed.[17] 1-MNA, a product inhibitor of NNMT[12, 24, 25] exhibited no passive permeability (Table 1)

This targeted mechanism allows enhanced fat oxidation and reduced lipogenesis, particularly in visceral and abdominal fat depots, making it a key subject in obesity and metabolic optimization research

doi: 10.1007/978-1-61779-430-8_27

[14] found that mice with NNMT knockdown have lower levels of fasting glucose and lower pyruvate conversion to glucose compared to control mice